Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling
نویسندگان
چکیده
منابع مشابه
Selective proinflammatory activation of astrocytes by high-mobility group box 1 protein signaling.
Extracellular high-mobility group box 1 protein (HMGB1) triggers inflammatory events in the brain. We demonstrate that astrocytes, the main glial cells in the brain, acquire a specific reactive phenotype when exposed to HMGB1. This cell activation, which involves the receptor for advanced glycation end-products and the MAPK/ERK1/2 cascade, results in the transcriptional/translational induction ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2007
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.179.12.8525